|Patient Type||Recommended Initial Daily Dose With or Without Meals|
With primary hypercholesterolemia or mixed dyslipidemia
|90 mg capsule once daily|
With severe hypertriglyceridemia*
|30 mg to 90 mg once daily†|
With mild to moderately impaired renal function‡
|30 mg once daily§|
*As studied in two randomized, double-blind, placebo-controlled clinical trials of 147 hypertriglyceridemic patients.
†Dosage should be individualized according to patient response and adjusted, if necessary.
‡Should be avoided in patients with severe renal impairment.
§Dose should be increased only after evaluation of effects on renal function and lipid levels.